Since 2015, we have been working with a CDC client focusing on Bacillus anthracis (B. anthracis) genome analysis and comparative genomics studies. In collaboration with these scientists, we have characterized sequencing data from various naturally occurring and laboratory constructed isolates, identifying novel variants and multi-copy plasmids and characterizing structural changes associated with drug resistance. This includes accurately characterizing variants associated with ciprofloxacin, penicillin, and clindamycin resistance. This work resulted in several publications in reputable journals.We have also created a bioinformatics pipeline for screening genomically engineered B. anthracis isolates and are developing a report generation software specific for this system, as well as a graphical user interface that allows for non-bioinformaticians to access this complete system. As we continue to work with this CDC client, our aim is to contribute to improving bioinformatics results interpretability and, therefore, time-sensitive responses to public health emergencies involving B. anthracis.

There are many sites and tools that track COVID-19 infection status and trends, however there is not a tool that calculates risk factors presenting in an event of various sizes. In collaboration with the Georgia Institute of Technology, IHRC created an online tool quantifying the risk as a pro-bono project. Soon, this project received many interests and received funding from both the government and private industry, including the Rockefeller Foundation. Released in early 2020, the site provides interactive context to assess the risk that one or more individuals infected with COVID-19 are present in an event of various sizes. These risk calculations provide support for the ongoing need for social distancing and other protective measures, which provides needed awareness for officials and the public.https://covid19risk.biosci.gatech.edu/